On the gating of mechanosensitive channels by fluid shear stress |
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Authors: | Zhangli Peng On Shun Pak Zhe Feng Allen P Liu Yuan-Nan Young |
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Institution: | 1. Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA;2. Department of Mechanical Engineering, Santa Clara University, Santa Clara, CA 95053, USA;3. Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA;4. Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ 07102, USA |
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Abstract: | Mechanosensation is an important process in biological fluid–structure interaction. To understand the biophysics underlying mechanosensation, it is essential to quantify the correlation between membrane deformation, membrane tension, external fluid shear stress, and con-formation of mechanosensitive (MS) channels. Smoothed dissipative particle dynamics (SDPD) simulations of vesi-cle/cell in three types of flow configurations are conducted to calculate the tension in lipid membrane due to fluid shear stress from the surrounding viscous flow. In combination with a simple continuum model for an MS channel, SDPD sim-ulation results suggest that shearing adhered vesicles/cells is more effective to induce membrane tension sufficient to stretch MS channels open than a free shear flow or a constrictive channel flow. In addition, we incorporate the bilayer–cytoskeletal interaction in a two-component model to probe the effects of a cytoskeletal network on the gating of MS channels. |
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Keywords: | Fluid-lipid membrane interaction Viscous flow Mechanosensitive channels Membrane tension |
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