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Conjugation of Peptide Nucleic Acid with a Pyrrole/Imidazole Polyamide to Specifically Recognize and Cleave DNA
Authors:Wataru Kameshima  Dr. Takumi Ishizuka  Dr. Masafumi Minoshima  Makoto Yamamoto  Prof. Dr. Hiroshi Sugiyama  Prof. Dr. Yan Xu  Prof. Dr. Makoto Komiyama
Affiliation:1. Research Center for Advanced Science and Technology, The University of Tokyo, 4‐6‐1 Komaba, Meguro‐ku, Tokyo 153‐8904 (Japan);2. Division of Chemistry, Department of Medical Sciences Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889‐1692 (Japan) http://www.miyazaki‐med.ac.jp/MMCCHEM/index_e_link_e.html;3. Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto (Japan);4. Current address: Life Science Center of Tsukuba Advanced Research Alliance University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8577 (Japan)
Abstract:
Keywords:amides  DNA recognition  DNA cleavage  noncovalent interactions  peptide nucleic acids
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