Ligand‐ and solvent‐free synthesis of 2‐aminobenzothiazoles by copper‐catalyzed tandem reaction of 2‐haloanilines with isothiocyanates |
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| Authors: | Ruiya Yao Haiyi Liu Yichao Wu Mingzhong Cai |
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| Institution: | Department of Chemistry, Jiangxi Normal University, , Nanchang, 330022 People's Republic of China |
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| Abstract: | We report an environmentally friendly, efficient and practical method for the synthesis of 2‐aminobenzothiazoles by a copper(II)‐catalyzed tandem reaction of 2‐haloanilines with isothiocyanates under ligand‐ and solvent‐free conditions in air. The developed methodology conforms to the principles of 'green chemistry' and addresses the shortage of such methods for the synthesis of 2‐aminobenzothiazoles. The reaction is quite general and generates a variety of 2‐aminobenzothiazoles in good to excellent yields. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | copper catalysis tandem reaction 2‐aminobenzothiazole solvent‐free 2‐haloaniline |
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