Conformation control of bilatrienes by peptides: A survey |
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Authors: | Daniel Krois Harald Lehner |
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Institution: | (1) Institut für Organische Chemie, Universität Wien, A-1090 Wien, Austria |
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Abstract: | Summary A variety of bilipeptides has been synthesized and investigated by UV-VIS and CD spectroscopy to explore the conformational influence of peptide ligands on the covalently bound tetrapyrrol moiety. The results obtained are complemented by those reported previously. From the comprehensive data thus available several features of the peptidic chain regulating interactions with the bilatriene moiety have been elucidated. Accordingly, the presence of three amide linkages at the ligand is prerequiste for induction of pronounced conformational changes consisting either in a complete transition ofM intoP helical bilatriene species by inversion of all torsional angles, or in a stretching of the chromophore. The kind of conformational influence can be controlled by varying the position of the prolyl entity within a given peptide.Dedicated to Prof. Dr. Kurt Schaffner on occasion of his 60th birthday |
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Keywords: | Bilipeptides Conformation control Chiral discrimination Bilatrienes non-helical |
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