Unusual selectivity of unprotected aziridines in palladium-catalyzed allylic amination enables facile preparation of branched aziridines |
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Authors: | Watson Iain D G Styler Sarah A Yudin Andrei K |
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Affiliation: | Davenport Research Laboratories, Department of Chemistry, The University of Toronto, Ontario, Canada. |
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Abstract: | Functionalized branched aziridines can be prepared in high yields and with high levels of regioselectivity using unprotected aziridines as nitrogen sources in palladium-catalyzed allylic amination. High levels of enantioselectivity can be achieved with BINAP on palladium. This methodology allows for strategic placement of an aziridine-containing fragment within a complex molecule environment for further elaboration. |
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