A general method for detecting protease activity via gelation and its application to artificial clotting |
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| Authors: | Bremmer Steven C Chen Jing McNeil Anne J Soellner Matthew B |
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| Institution: | Department of Medicinal Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan, 48109-1055, USA. |
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| Abstract: | A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma. |
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