Highly stereoselective reductions of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters catalyzed by isolated NADPH-dependent ketoreductases |
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| Authors: | Kalaitzakis Dimitris Rozzell J David Kambourakis Spiros Smonou Ioulia |
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| Affiliation: | Department of Chemistry, University of Crete, Greece. |
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| Abstract: | ![]()
[reaction: see text] The biocatalytic reduction of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters. |
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