Thermal behaviour of some novel antimicrobials based on complexes with a Schiff base bearing 1,2,4-triazole pharmacophore |
| |
Authors: | Mihaela Badea Larisa Calu Mariana Carmen Chifiriuc Coralia Bleotu Alexandra Marin Sebastian Ion Gabriela Ioni?? Nicolae Stanic? Lumini?a M?ru?escu Veronica Laz?r Dana Marinescu Rodica Olar |
| |
Institution: | 1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str. Sector 5, 050663, Bucharest, Romania 2. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str, 60101, Bucharest, Romania 3. Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest, Romania 4. “Ilie Murgulescu” Physical Chemistry Institute, Romanian Academy, 202 Splaiul Independentei, 77208, Bucharest, Romania
|
| |
Abstract: | A series of complexes of type ML(CH3COO)(OH2)2] (M: Co, Ni; HL: 2-(E)-1H-1,2,4-triazol-3-ylimino)methyl]phenol)) and M2L2(CH3COO)2(OH2)n] (M: Cu, n = 2; M: Zn, n = 0) were synthesised by template condensation. The compounds were characterised with microanalytical, ESI–MS, IR, electronic, EPR spectra and magnetic data at room temperature. Based on the IR and ESI–MS spectra, a dinuclear structure with the acetate as bridge was proposed for Cu(II) and Zn(II) complexes. The dinuclear structure of Cu(II) complex is also consistent with both magnetic behaviour and EPR spectrum. The thermal analyses have evidenced processes as water elimination, acetate decomposition, as well as oxidative degradation of the Schiff base. The final decomposition product was the most stable metal oxide as indicated by powder X-ray diffraction. The cobalt and copper compounds exhibited a broad spectrum of antibacterial activity towards both planktonic and biofilm-embedded cells. The complexes exhibit a low cytotoxicity except for Cu(II) species that induces the early apoptosis for the HEp 2 cells. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|