(R)-α-烷基糠胺的不对称合成

本文通过(+)-樟脑缩呋喃甲亚胺的不对称烷基化反应, 合成了(R)-α)-烷基糠胺。反应的非对映选择性经1H NMR测定为5～67%(d.e)。用1, 3-二碘丙烷和α, α-二溴邻二甲苯作烷基化试剂, 得到预期的双亚胺烷基产物, 而用1,2-二溴乙烷时,却给出偶联产物。

Studies on the asymmetric synthesis of (R)-α-alkyl-furfuryl amines

(R)-α-alkyl-furfuryl amines are synthesized by asymmetric alkylation of (+)-camphor ketimine (3) from furfuryl amine. the diastereoselectivities ranging from 5～67% are determined by 1H NMR spectra of alkylation products (6a～6e). using 1, 3-diiodopropane and dibromoxyiene as alkylatingreagents, diimine dervatives (6f～6g) are formed. however, 1,2-dibromothane gives coupling product (6h).