Cu(II)-氨基酸-核苷酸三元配合物的合成和表征

合成和表征Na~2Cu(L-Ala)~2(5'-GMP)].2H~2O、Na~2Cu(L-Ala)~2(5'-IMP)].6H~2O、Na~2Cu(L-His)(5'-GMP)Cl~2^2.2H~2O和Na~2Cu(L-His)(5'-IMP)Cl~2].H~2O四个新的三元配合物, 其中两个L-Ala分子通过羧基O和α-氨基N与Cu(II)成反式配位, 一个L-His分子通过羧基O和咪唑环上的N与Cu(II)配位; 一个5'-GMP或5'-IMP分子嘌呤环上的N(7)与Cu(II)配位; 5'-GMP的磷酸根上可能存在强氢键, 而5'-IMP的磷酸根上不存在强氢键; 在含L-Ala三元配合物中, 5'-GMP的C(6)=0可能参与配位或形成强氢键, 而5'-IMP的C(6)=0不参与配位或形成配位或形成强氢键; 在含L-His三元配合物中, 5'-IMP的C(6)=0的表现则相反。

Synthesis and characterization of ternary complexes containing Cu(II) amino acid an 1 nucleotide

The study on metal-amino acid-nucleotide ternary complexes may provide a model for the more complicated metal-protein-nucleic acid interaction. The ternary complexes containing Cu(II), amino acid (L-Ala and L-His) and nucleotide (5'-GMP and 5'-IMP) were synthesized and characterized. In these complexes the O atom at carboxylate group and the N atom at a-amino group of 2 L-Ala coordinate with Cu(II), the O atom at carboxylate group and the N atom at the imidazole ring of a L-His coordinate with Cu(II), and the N(7) atom of purine ring of 5'-GMP or 5'-IMP coordinates with Cu(II) too. There is interaction between phosphate group of 5'-GMP with L-Ala or L-His, but no interaction in 5'-IMP ternary complexes. The C(6):O of purine for 5'-GMP or 5'-IMP may be coordinating with Cu(II) or forming H bond.