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A Solution-Phase Parallel Synthesis of 5-Substituted 3,6-Dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-ones
Authors:Shaofa Sun  Li Chen  Xuhong Yang
Affiliation:Department of Chemistry and Life Science, Xianning College, Xianning, Hubei 437000, China
Abstract:
5‐Substituted 7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐ones ( 4 ) were rapidly prepared by a solution‐phase parallel synthetic method, which includes aza‐Wittig reaction of iminophosphorane ( 1 ) with phenyl isocynate to give carbodiimide ( 2 ) and subsequent reaction of 2 with various amine and alcohols in the presence of catalytic amount of sodium alkoxide in a parallel fashion.
Keywords:aza‐Wittig reaction  triazolo[4,5‐d]pyrimidin‐7‐one  parallel synthesis  isocyanate
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