A Solution-Phase Parallel Synthesis of 5-Substituted 3,6-Dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-ones |
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Authors: | Shaofa Sun Li Chen Xuhong Yang |
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Affiliation: | Department of Chemistry and Life Science, Xianning College, Xianning, Hubei 437000, China |
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Abstract: | 5‐Substituted 7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐ones ( 4 ) were rapidly prepared by a solution‐phase parallel synthetic method, which includes aza‐Wittig reaction of iminophosphorane ( 1 ) with phenyl isocynate to give carbodiimide ( 2 ) and subsequent reaction of 2 with various amine and alcohols in the presence of catalytic amount of sodium alkoxide in a parallel fashion. |
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Keywords: | aza‐Wittig reaction triazolo[4,5‐d]pyrimidin‐7‐one parallel synthesis isocyanate |
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