| 海带硫酸多糖防止草酸钙结石形成的体外模拟 |
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| 引用本文： | 王青豪,郑辉,吴秀梅,欧阳建明.海带硫酸多糖防止草酸钙结石形成的体外模拟[J].人工晶体学报,2006,35(6):1296-1300. |
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| 作者姓名： | 王青豪 郑辉 吴秀梅 欧阳建明 |
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| 作者单位： | 赣南师范学院化学与生命科学学院,赣州,341000;暨南大学生物矿化与结石病防治研究所,广州,510632 |
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| 基金项目： | Project supported by the Key Project of Guangdong Province(2006 B 36501001)and the National Natural Science Foundation ofChina(No.20471024) |
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| 摘 要： | 采用扫描电子显微镜、X射线衍射法和红外光谱在草酸钙(CaOxa)结石患者尿液中研究了从海带中提取的硫酸多糖(LSPS)的防石作用.结果表明,LSPS可以抑制一水草酸钙(COM)的成核和聚集,并诱导二水草酸钙(COD)晶体形成.随着ESPS浓度从0增加到0.005, 0.02和0.20 mg/ml,COD的百分含量从0分别增加到22;, 55;和100;.这些结果表明LSPS是抑制CaOxa结石形成的一种潜在药物.
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| 关 键 词： | 草酸钙 硫酸多糖 尿结石 生物矿化 |
| 文章编号： | 1000-985X（2006）06-1296-05 |
| 收稿时间： | 04 12 2006 12:00AM |
| 修稿时间： | 2006-04-12 |
Simulation in Vitro on Inhibition of Calcium Oxalate Calculus in Lithogenic Urine by Sulfated Polysaccharide Isolated from Laminarin |
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| WANG Qing-hao,ZHENG hui,WU Xiu-mei,OUYANG Jian-ming.Simulation in Vitro on Inhibition of Calcium Oxalate Calculus in Lithogenic Urine by Sulfated Polysaccharide Isolated from Laminarin[J].Journal of Synthetic Crystals,2006,35(6):1296-1300. |
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| Authors: | WANG Qing-hao ZHENG hui WU Xiu-mei OUYANG Jian-ming |
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| Institution: | 1. College of Chemistry and Life Science, Gannan Normal University, Ganzhou 341000,China; 2. Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632 ,China |
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| Abstract: | The inhibition of calcium oxalate(CaOxa) urinary stone by sulfated polysaccharide(LSPS) isolated from marine algae Laminarin was investigated in lithogenic urine by means of scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy.LSPS can inhibit the nucleation and aggregation of calcium oxalate monohydrate(COM) crystals,and induce the formation of calcium oxalate dihydrate(COD) crystals.With the concentration of LSPS increases from 0 to 0.005,(0.02) and 0.20 mg/mL,the percentage of COD crystals increased from 0 to 22%,55% and 100%,respectively.It indicated that LSPS maybe a potential inhibitor to CaOxa urinary stones. |
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| Keywords: | calcium oxalate sulfated polysaccharid urinary stone biomineralization |
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