General synthesis of polysubstituted thiophenes from diketo sulfides |
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| Authors: | Juzo Nakayama Haruki Machida Ryuji Saito Masamatsu Hoshino |
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| Affiliation: | Department of Chemistry, Faculty of Science, Saitama University Urawa, Saitama 338, Japan |
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| Abstract: | Treatment of diketo sulfides with a low-valent titanium reagent at 0 °C (in two cases at room temperature) affords 3,4-dihydroxythiolanes in good yields. The acid-catalyzed (p-toluenesulfonic acid) dehydration of the latter compounds leads to the corresponding thiophenes in excellent yields. |
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