Synthetic studies on carbapenem antibiotics from penicillins. IV. Stereoselective kinetic protonation of a chiral azetidinone enolate期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Synthetic studies on carbapenem antibiotics from penicillins. IV. Stereoselective kinetic protonation of a chiral azetidinone enolate

Authors:	Hideo Hirai Kozo Sawada Matsuhiko Aratani Masashi Hashimoto

Institution:	1. Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka 532, Japan;2. Central Laboratories Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka 532, Japan

Abstract:	A stereoselective kinetic protonation of the azetidinone enolate $B$ was studied and an efficient synthesis of $2$ (cis) was achieved via aldol reaction of $5$ with acetone followed by the kinetic protonation with Ph₃SnH as proton source.

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