Structure of seven new vibsane-type diterpenoids from Viburnum awabuki |
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| Institution: | 1. Institute of Research and Development, Duy Tan University, 03 Quang Trung, Da Nang, Viet Nam;2. Ivanovo State University of Chemistry and Technology, Sheremetievskiy Ave., 7, Ivanovo, 153000, Russian Federation;3. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Sciences, 1 Favorsky Street, 664033, Irkutsk, Russian Federation;1. School of Pharmaceutical Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, People’s Republic of China;2. Marshall Laboratory of Biomedical Engineering, Shenzhen University, Shenzhen 518060, People’s Republic of China |
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| Abstract: | Seven new vibsane-type diterpenoids, 6-O-methyl-6,7-dihydroxyvibsanin B (1), 4-hydroxyvibsanin A (2), 14(R*),15-epoxyneovibsanin B (3), 14(S*),15-epoxyneovibsanin B (4), (8Z)-neovibsanin B (5), 18-O-methylvibsanin C (6), and (8Z)-vibsanin E (7), have been isolated from the leaves of Viburnum awabuki. Their structures have been elucidated by molecular mechanics 2 (MM2) calculations and comparison of the spectroscopic data, including 13C NMR data, with those of previously known compounds. Moreover, neovibsane-type diterpenoids 3, 4, and 5 enhanced the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 40 μM. |
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| Keywords: | Caplifoliaceae Vibsane-type diterpenoid Neurite outgrowth-promoting activity PC12 cells |
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