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Regioselective bromination of aryl ureas with Phenyliodine(III) diacetate and potassium bromide
Institution:1. Hubei Province Key Laboratory for Coal Conversion and New Carbon Materials, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, PR China;2. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China;3. College of Chemistry and Chemical Engineering, Tiangong University, Tianjing 300387, PR China;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand;2. Institute of Quantum Beam Science, Ibaraki University, Mito, 310-8512, Japan;1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi 330013, PR China;2. Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, PR China;1. School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, PR China;2. Department of Pharmaceutical Preparation, Hangzhou Xixi Hospital, Hangzhou, Zhejiang 310023, PR China;3. Department of Pharmacy, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, PR China;1. CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, PR China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, 730000, PR China
Abstract:An efficient regioselective and operationally simple urea bromination method utilizing PIDA and potassium bromide is reported. This protocol proved to be effective on a broad range of substituted ureas in acetone at room temperature, forming the p-brominated compounds in 44–86% yields.
Keywords:Bromination  Regioselective  PIDA  Metal-free  Potassium bromide
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