新型可降解纳米药物ZnO2@Fe3+-TA@PVP用于肿瘤的化学动力学治疗

为了提高化学动力学疗法的治疗效果, 设计制备了一种新颖的可降解纳米药物ZnO₂@Fe³⁺-TA@PVP. 在弱酸性的肿瘤微环境中, 该纳米药物可降解为Zn²⁺, Fe³⁺, 单宁酸(TA)和H₂O₂, 实现了肿瘤微环境内H₂O₂的自供给. 同时, 释放出的Fe³⁺被TA进一步还原成Fe²⁺, 实现了肿瘤原位Fe²⁺的自生成, 并进一步与H₂O₂发生芬顿反应生成毒性的羟基自由基(·OH), 从而实现对肿瘤细胞特异性的化学动力学治疗. 此外, Zn²⁺通过抑制线粒体电子传递链(ETC)来促进内源性超氧阴离子(·O{}_{\mathrm{2}}^{-})的产生, 从而协同提高了治疗效果.

Novel Biodegradable Nanodrugs ZnO2@Fe3+-TA@PVP for Chemodynamic Therapy

A novel biodegradable nanodrugs ZnO₂@Fe³⁺-TA@PVP for further improving the treatment effect of chemodynamic therapy（CDT） was prepared. In the acidic tumor microenvironment， ZnO₂@Fe³⁺-TA@PVP could be degraded to Zn²⁺， Fe³⁺， tannic acid（TA） and H₂O₂， achieving H₂O₂ self-supply. Moreover， Fe³⁺ ions were further reduced to Fe²⁺ by TA， realizing the self-generation of Fe²⁺ in the tumor site. Fenton reaction occurred between Fe²⁺ and H₂O₂ to produce high toxic ·OH， which realized efficient CDT. Meanwhile， Zn²⁺ ions inhibited the mitochondrial electron transport chain（ETC） to promote the production of endogenous superoxide anion（·O{}_{\mathrm{2}}^{-}）， thus synergistically improving the therapeutic effect.