首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions
Institution:1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Lushan South Rd. 2, Changsha, 410082, PR China;2. State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co.,Ltd, Dongguan, 523871, PR China;1. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan;2. Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, 82144, Taiwan;1. Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt;2. Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo, Egypt;3. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, Saudi Arabia;4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt;1. Department of Applied Chemistry, School of Science, Anhui Agricultural University, Hefei, Anhui, 230036, PR China;2. Soil and Fertilizer Institute of Anhui Academy of Agricultural Science, Hefei, Anhui 230001, PR China;1. College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, PR China;2. Hunan Province Cooperative Innovation Center for the Construction & Development of Dongting Lake Ecologic Economic Zone, Hunan University of Arts and Science, Changde 415000, PR China;1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China;2. The State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co. Ltd, Dongguan 523871, PR China
Abstract:An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.
Keywords:Mukaiyama-reagent  Metal-free  Mild conditions  Alkynyl sulfones  Alkynyl phosphonates
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号