Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis |
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| Authors: | Njardarson Jon T Biswas Kaustav Danishefsky Samuel J |
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| Institution: | Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, NY 10021, USA. |
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| Abstract: | A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki-Kishi macrocyclization is described. |
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