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Total Synthesis of Sporolide B |
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| Authors: | K. C. Nicolaou Prof. Dr. Yefeng Tang Dr. Jianhua Wang |
| Affiliation: | 1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1)?858‐784‐2469;2. Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA) |
| Abstract: | An ocean of discovery : The first total synthesis of the highly oxygenated, marine‐derived, natural product sporolide B has been achieved through a convergent strategy. The key steps involve a ruthenium‐catalyzed [2+2+2] cycloaddition to assemble the indene structural motif and a thermally induced Diels–Alder‐type reaction to forge the macrocycle (see scheme).  |
| Keywords: | cycloaddition Diels– Alder reactions natural products o‐quinones total synthesis |