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Stabilization of an α Helix by β‐Sheet‐Mediated Self‐Assembly of a Macrocyclic Peptide
Authors:Yong‐beom Lim Dr.  Kyung‐Soo Moon  Myongsoo Lee Prof.
Affiliation:Center for Supramolecular Nano‐Assembly and Department of Chemistry, Yonsei University, Seoul 120‐749 (Korea), Fax: (+82) 2‐393‐6096 http://csna.yonsei.ac.kr
Abstract:Protein roll call : Peptide‐based building blocks, in which both an α‐helix‐forming segment and a β‐sheet segment are located within a single macrocyclic structure, self‐assemble into α‐helix‐decorated artificial proteins. This approach provides a starting point for developing artificial proteins that can modulate α‐helix‐mediated interactions occurring in a multivalent fashion.
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Keywords:helical structures  macrocycles  nanostructures  protein models  self‐assembly
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