Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Meguro‐ku, Tokyo 153‐8904 (Japan), Fax: (+81)?3‐5254‐5201, http://www.mkomi.rcast.u‐tokyo.ac.jp/index.html
Abstract:
A trap that closes with a “click” : The copper‐catalyzed azide–alkyne cycloaddition can occur in different G‐quadruplex structures (see scheme). The species trapped by the click reaction can then be separated and analyzed. By using this approach, a DNA–RNA hybrid‐type G‐quadruplex structure formed by human telomeric DNA and RNA sequences was detected.
