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Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars |
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| Authors: | Pamela V. Chang Xing Chen Chris Smyrniotis Alexander Xenakis Tianshun Hu Carolyn R. Bertozzi Prof. Peng Wu Prof. |
| Affiliation: | 1. Departments of Chemistry and Molecular Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, and The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (USA), Fax: (+1)?510‐643‐2628;2. These authors contributed equally to the work.;3. Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461 (USA), Fax: (+1)?718‐678‐1022 |
| Abstract: | Sialome sweet sialome : As sialic acids are involved in many host–pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N‐(4‐pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.  |
| Keywords: | alkynes click chemistry glycobiology nonnatural sugars sialic acids |