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Oxidase‐Like Activity of Polymer‐Coated Cerium Oxide Nanoparticles |
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| Authors: | Atul Asati Santimukul Santra Dr. Charalambos Kaittanis Sudip Nath Dr. J. Manuel Perez Prof. |
| Affiliation: | Nanoscience Technology Center, Department of Chemistry and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA), Fax: (+1)?407‐882‐2843 http://www.nanoscience.ucf.edu/faculty/perez.php |
| Abstract: | Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase‐like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).  |
| Keywords: | cerium immunoassays nanotechnology oxidases oxidation |