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Estimating the lipophilicity of a number of 2‐amino‐1‐cyclohexanol derivatives exhibiting anticonvulsant activity |
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| Authors: | El?bieta P?kala Henryk Marona |
| Institution: | Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30‐688 Cracow, Poland |
| Abstract: | The lipophilicity of a number of N‐acyl derivatives of trans‐ or cis‐: racemic, (1R,2R)‐ or (1S,2S)‐aminocyclohexanol (1–13) exhibiting anticonvulsant activity was investigated. Their lipophilicity (Rm 0) was determined using reversed‐phase thin‐layer chromatography (RP‐TLC) with mixtures of methanol and water as mobile phases. The partition coefficients of compounds 1–13 (log P) were also calculated using two computer programs (Pallas and Chem DU) and compared with Rm 0. Copyright © 2009 John Wiley & Sons, Ltd. |
| Keywords: | 2‐amino‐1‐cyclohexanol reversed‐phase thin‐layer chromatography lipophilicity retention parameter Rm0 calculated partition coefficient log P anticonvulsant activity quantitative structure– activity relationship |