1. Department of Chemistry, Yonsei University, Seoul 120‐749 (Korea), Fax: (+82)?2‐364‐7050;2. These authors contributed equally.;3. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305‐701 (Korea), Fax: (+82)?42‐869‐2610
Abstract:
Cancer‐cell‐targeted gene silencing was observed with a magnetic‐nanoparticle platform (MEIO, magnetism‐engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD‐peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
