Investigation of sp2–sp Coupling for Electron‐Enriched Aryl Dihalides under Oxygen‐Free Sonogashira Coupling Reaction Conditions Using a Two‐Chamber Reaction System
1. Department of Chemistry, University of Missouri‐ Kansas City, Kansas City, MO 64110 (USA), Fax: (+1)?816‐235‐5502;2. Department of Chemistry, University of Missouri‐Columbia, Columbia, MO 65211 (USA)
Abstract:
Triethylamine hydroiodide crystals were formed during Sonogashira reactions; after complete reaction the solution retains a characteristic light color (see picture). Very sluggish Sonogashira reactions of electron‐enriched aryl diiodides have been carried out in high yield in an oxygen‐free, two‐chamber reaction system. The formation of triethylamine hydroiodide crystals was monitored to determine the completion of reaction.
