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Cognitive‐Performance Recovery of Alzheimer's Disease Model Mice by Modulation of Early Soluble Amyloidal Assemblies |
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| Authors: | Anat Frydman‐Marom Meirav Rechter Irit Shefler Yaron Bram Deborah?E Shalev Dr Ehud Gazit Prof |
| Institution: | 1. Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978 (Israel), Fax: (+972)?3‐640‐9407;2. Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904 (Israel) |
| Abstract: | A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid‐β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique Cα‐methylation β‐breakage strategy. The electrostatic potential of the low‐energy conformation of the dipeptide inhibitor bound to Aβ is shown.  |
| Keywords: | amyloid assemblies inhibitors oligomers peptides self‐assembly |