Department of Chemistry, University of Waterloo, 200 University Ave. West, Waterloo, Ontario, N2L 3G1 (Canada), Fax: (+1)?519‐746‐0435
Abstract:
Double protection : Efficient Fmoc‐based solid‐phase synthesis (SPPS) of sulfotyrosine (sY) peptides is achieved by incorporating the sY residue(s) as a dichlorovinyl‐protected (DCV) sulfodiester(s) and using 2‐methylpiperidine for Fmoc removal. After removal of the other protecting groups, the DCV group could be cleaved by mild hydrogenolysis giving the sY peptides in good yield.
