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Non‐Hydrolyzable RNA–Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3′‐Peptidyl tRNA Termini |
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| Authors: | Holger Moroder Jessica Steger Dagmar Graber Katja Fauster Krista Trappl Viter Marquez Dr Norbert Polacek Priv‐Doz Dr Daniel N Wilson Dr Ronald Micura Prof Dr |
| Institution: | 1. Institute of Organic Chemistry, Center for Molecular Biosciences CMBI, University of Innsbruck, 6020 Innsbruck (Austria), Fax: (+43)?507‐512‐2892;2. Innsbruck Biocenter, Medical University of Innsbruck, Divison of Genomics and RNomics, 6020 Innsbruck (Austria);3. Gene Center, Department for Chemistry and Biochemistry and Center for Integrated Protein Science (CiPS‐M), Ludwig‐Maximillians‐Universit?t, 81377 Munich (Germany) |
| Abstract: | Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA–peptide conjugates that mimic peptidyl‐tRNA would be desirable, especially for ribosome structural biology. A flexible solid‐phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.  |
| Keywords: | oligonucleotides peptidyl‐tRNA ribosomes RNA solid‐phase synthesis |