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Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold |
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| Authors: | David Coquière Dr. Jeffrey Bos Joris Beld Gerard Roelfes Dr. |
| Affiliation: | 1. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands), Fax: (+31)?50‐363‐4296 http://roelfes.fmns.rug.nl;2. Laboratorium für Organische Chemie, ETH Zürich, H?nggerbergg HCI, 8093 Zürich (Switzerland) |
| Abstract: | Site creation : Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels–Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.  |
| Keywords: | artificial metalloenzymes asymmetric catalysis copper Diels– Alder reactions Michael addition |