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A Reduced SNARE Model for Membrane Fusion |
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| Authors: | Hana Robson Marsden Nina A. Elbers Paul H. H. Bomans Dr. Nico A. J. M. Sommerdijk Dr. Alexander Kros Dr. |
| Affiliation: | 1. Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden (The Netherlands), Fax: (+31)?71‐527‐4397, http://wwwchem.leidenuniv.nl/scm/alexander/Index%20site%20akros.htm;2. Laboratory of Materials and Interface Chemistry and Soft Matter CryoTEM Research Unit, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands) |
| Abstract: | Let's get together : A minimal model system was developed to mimic the SNARE‐protein‐mediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled‐coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events.  |
| Keywords: | coiled coils lipopeptides liposomes membrane fusion SNARE proteins |