The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products |
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| Authors: | Daisuke Iijima |
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| Institution: | Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | SB87-Cl 1, an inhibitor of testosterone-5α-reductase, and pestalone 2 exhibiting effective antimicrobial activity against MRSA (MIC = 37 ng/mL) and VRE (MIC = 78 ng/mL), were novel bioactive benzophenone natural products. Total synthesis of 1 and 2 has been successfully accomplished. The common synthetic precursor 18 of 1 and 2, was successfully obtained by the coupling of 8 with 12. |
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| Keywords: | SB87-Cl Testosterone-5α-reductase Chrysosporium Pestalone Pestalotia MRSA VRE |
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