Control of electron demand in the cycloadditions of 2(H)-1,4-oxazin-2-ones |
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| Authors: | Kamyar Afarinkia Akmal Bahar Maushami Vyas |
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| Institution: | a Department of Chemistry, King’s College, Strand, London WC2R 2LS, UK
b Celltech R&D Ltd., 208 Bath Road, Slough, Berkshire, SL1 3WE, UK |
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| Abstract: | 3-Methoxy-5-chloro-6-methyl-2(H)-1,4-oxazin-2-one 4, 3-methoxy-5-chloro-6-phenyl-2(H)-1,4-oxazin-2-one 5, 3-phenylsulfenyl-5-chloro-6-methyl-2(H)-1,4-oxazin-2-one 6, and 3-phenylsulfenyl-5-chloro-6-phenyl-2(H)-1,4-oxazin-2-one 7, are ambident dienes and undergo Diels-Alder cycloadditions with electron neutral, rich and deficient dienophiles. |
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| Keywords: | 2(H)-1 4-Oxazin-2-ones Diels-Alder Cycloaddition |
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