Zyzzyanone A, a novel pyrrolo[3,2-f]indole alkaloid from the Australian marine sponge Zyzzya fuliginosa |
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Authors: | Natalia K Utkina Aleksandra E Makarchenko Pavel S Dmitrenok |
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Institution: | a Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 690022 Vladivostok, Russia b Department of Bioorganic Chemistry and Biotechnology, Far Eastern State University, 690600 Vladivostok, Russia |
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Abstract: | A new dipyrroloquinone, zyzzyanone A 1, having a pyrrolo3,2-f]indole-4,8(1H,7H)-dione skeleton, was isolated from the Australian marine sponge Zyzzya fuliginosa, along with the known pyrroloquinoline alkaloids, makaluvamines C, E, G, H, and L, and damirones A and B. The structure of 1 was determined by spectroscopic data. Zyzzyanone A 1 shows moderate cytotoxic activity against mouse Ehrlich carcinoma cells (IC50 25 μg/mL), inhibits the cell division of fertilized sea urchin eggs at a concentration of 25 μg/mL, and exhibits UV-A and UV-B absorbing activity. |
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Keywords: | Sponges Dipyrroloquinones Pyrrolo[3 2-f]indole Pyrrolo[4 3 2-de]quinoline Alkaloids |
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