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Aziridination of γ,δ-dibromoethyl-2-pentenoate with primary amines: extension of the Gabriel-Cromwell reaction |
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| Authors: | Rachel L. Weller |
| Affiliation: | a The School of Pharmacy, University of Wisconsin, Madison, WI 53705-2222, USA b Department of Chemistry, University of Wisconsin, Madison, WI 53706-1396, USA |
| Abstract: | Ethyl (E)-4,5-dibromo-2-pentenoate readily reacts with an assortment of primary amines in the presence of DBU to afford the corresponding conjugated aziridines in good to moderate yields. That the reaction is compatible with a nucleoside-derived amine suggests a broad scope of application. |
| Keywords: | Nucleoside Aziridination Cofactor Gabriel-Cromwell |
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