Mechanism of an unusual decarboxylative cyclization |
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| Authors: | Andrew S Kende Olivier Henry Zecheng Chen |
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| Institution: | Department of Chemistry, University of Rochester, Rochester, NY 14627, USA |
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| Abstract: | The mechanism of an unusual decarboxylative cyclization from 5-methoxy-1-(2-carboxyphenyl)-1,4-dihydro-4-oxopyridine-2-carboxylic acid (diacid) to 3-methoxypyrido1,2-a]indole-2,10-dione (ketone) has been investigated. 13C-labeling has demonstrated that the carbonyl carbon of the ketone arises exclusively from the anthranilic acid carboxyl of the diacid. A zwitterionic mechanism has been proposed. |
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| Keywords: | Mechanism Decarboxylative cyclization |
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