A new synthesis of oxcarbazepine using a Friedel-Crafts cyclization strategy |
| |
Authors: | Daniel Kaufmann Peter C Fünfschilling Ulrich Beutler Pascale Hoehn Olivier Lohse Werner Zaugg |
| |
Institution: | Novartis Pharma AG, Chemical and Analytical Development, CH-4002 Basel, Switzerland |
| |
Abstract: | A novel, simple, and straightforward process for the large-scale synthesis of oxcarbazepine, the active ingredient of Trileptal®, a medicine for the treatment of epilepsy, has been developed. Starting from readily available 1,3-dihydro-1-phenyl-2H-indol-2-one, a Friedel-Crafts cyclization strategy provides a direct route to the tricyclic framework of the target molecule. Crucial to the success of the strategy was the choice of the proper nitrogen-protecting group. |
| |
Keywords: | Friedel-Crafts acylation Oxcarbazepine |
本文献已被 ScienceDirect 等数据库收录! |
|