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The modified `phosphine imide' reaction: a safe and soft alternative ureas synthesis |
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| Authors: | Stanislaw Porwanski Xavier Marsura |
| Affiliation: | a Department of Organic and Applied Chemistry, University of Lodz, ul.Naturowicza 68, 90-136 Lodz, Poland b G.E.V.S.M. Unité Mixte de Recherche du CNRS 7565, Structure et Réactivité des Systèmes, Moléculaires Complexes, Faculté des Sciences Pharmaceutiques 5, rue A. lebrun 5400, B.P. 403 Nancy cedex, France |
| Abstract: | In this work we present a new way for the direct and general synthesis of urea compounds from primary amines by the modified `phosphine imide' reaction. A large panel of amine structures are compatible with the smooth reaction conditions. Particularly in the case of sensitive l-aminoesters, it is interesting to note that the stereochemistry at the asymmetric centre was unmodified in the reaction conditions. |
| Keywords: | Urea formation Modified phosphine imide reaction |
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