A versatile and practical synthesis of bis(indolyl)methanes/bis(indolyl)glycoconjugates catalyzed by trichloro-1,3,5-triazine |
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| Authors: | GVM Sharma J Janardhan Reddy P Sree Lakshmi Palakodety Radha Krishna |
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| Institution: | D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A practical and efficient electrophilic substitution reaction of indoles with a variety of aldehydes was carried out using catalytic trichloro-1,3,5-triazine (10 mol %) in acetonitrile to furnish the corresponding bis(indolyl)methanes in excellent yields. Similarly, sugar derived aldehydes gave hitherto unknown bis(indolyl)glycoconjugates in very good yields. |
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| Keywords: | Bis(indolyl)methanes Aldehydes Sugar aldehydes Electrophilic substitution Trichloro-1 3 5-triazine |
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