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One-pot synthesis of 5-(substituted-amino)pyrazoles |
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| Authors: | Dharmpal S Dodd Rogelio L Martinez |
| Affiliation: | a Early Discovery Chemistry, Bristol-Myers, Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA b New Leads Chemistry-Applied Biotechnology, Bristol-Myers, Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA |
| Abstract: | An efficient and mild one-pot synthesis of substituted 5-alkylamino and/or 5-(arylamino)pyrazoles is described. A suitably decorated β-ketoamide, an aryl or alkyl hydrazine and Lawesson's reagent are suspended in THF/Py and gently heated to yield the requisite 5-aminopyrazoles. |
| Keywords: | 5-Aminopyrazoles 5-Alkylaminopyrazoles β-ketoamides |
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