2-Pivalamido-3H-pyrimidin-4-one derivatives: convenient pivalamide hydrolysis using Fe(NO3)3 in MeOH |
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| Authors: | V Bavetsias EA Henderson E McDonald |
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| Institution: | Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research, Chemistry Department, Cancer Research UK Laboratory, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK |
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| Abstract: | A simple methodology for pivalamide (trimethylacetamide, pivaloylamino) hydrolysis has been discovered using Fe(NO3)3 in MeOH at room temperature. The pivalamido group of 2-pivalamido-3H-pyrimidin-4-ones or fused 2-pivalamido-3H-pyrimidin-4-ones such as 2-pivalamido-3H-quinazolin-4-ones and 2-pivalamido-3H-pteridines have been hydrolysed under these conditions to afford the corresponding amine. |
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| Keywords: | 2-Pivalamido-3H-pyrimidin-4-ones Hydrolysis Fe(NO3)3 |
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