First synthesis of arylpyrrolo- and pyrazolopyrrolizinones as useful agents with potential biological interest |
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| Authors: | Christophe Rochais Vincent Lisowski Patrick Dallemagne Sylvain Rault |
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| Affiliation: | a Centre d'Etudes et de Recherche sur le Médicament de Normandie, 1 rue Vaubénard 14032 Caen Cedex, France
b UFR des Sciences Pharmaceutiques, Boulevard Becquerel 14032 Caen Cedex, France |
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| Abstract: | Novel arylpyrrolo- and pyrazolopyrrolizinones were prepared in three or four steps starting from aminoarylpyrrole and pyrazole carboxylates through the cyclisation of a Vilsmeier-Haack intermediate. This synthesis was enhanced by diverse N-protections of the aza-heterocycle and furnish new series with potential biological interest. |
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| Keywords: | Cyclisation Pyrroles Pyrazoles Fused-ring systems |
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