Silver-catalysed hydroamination: synthesis of functionalised pyrroles |
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| Authors: | Ross S Robinson David Gravestock |
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| Institution: | Warren Research Laboratory, School of Chemistry, University of KwaZulu-Natal, Corner of Golf and Ridge Roads, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa |
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| Abstract: | It has been shown that functionalised pyrroles can be efficiently prepared using a two-step sequence. This sequence involves the propargylation of secondary enaminones using n-BuLi and propargyl bromide, followed by intramolecular hydroamination catalysed by silver nitrate. The hydroamination can be carried out at room temperature (overnight) or in a domestic microwave oven (60 s). |
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| Keywords: | Amination Pyrroles Silver and compounds Microwave heating |
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