|
|||||
|
|
Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust |
|
| Authors: | Hosahydya N Gopi Vommina V Suresh Babu |
| Institution: | Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore - 560 001, India |
| Abstract: | Coupling of Fmoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. The coupling is reasonably fast, clean, racemization free and high yielding. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |