Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter |
| |
| Authors: | Ryo Shintani Tomoaki Ito Midori Nagamoto Haruka Otomo Tamio Hayashi |
| |
| Institution: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. shintani@kuchem.kyoto-u.ac.jp. |
| |
| Abstract: | A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of γ-methylidene-δ-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
