Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX |
| |
| Authors: | Brett Waybrant Timothy R Pearce Ping Wang Srinand Sreevatsan Efrosini Kokkoli |
| |
| Affiliation: | Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA. kokkoli@umn.edu. |
| |
| Abstract: | ![]()
Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
