O‐Benzyl‐N‐tert‐butoxycarbonyl‐N‐methyl‐l‐tyrosine |
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Authors: | Elbieta Jankowska Mirosaw Gilski Mariusz Jasklski Zbigniew Grzonka Leszek ankiewicz |
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Institution: | El?bieta Jankowska,Miros?aw Gilski,Mariusz Jaskólski,Zbigniew Grzonka,Leszek ?ankiewicz |
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Abstract: | The crystal structure of the title compound, alternatively called 3‐4‐(benzyloxy)phenyl]‐2‐(N‐tert‐butoxycarbonyl‐N‐methylamino)propionic acid, C22H27NO5, has been studied in order to examine the role of N‐methylation as a determinant of peptide conformation. The conformation of the tert‐butoxycarbonyl group is trans–trans. The side chain has a folded conformation and the two phenyl rings are effectively perpendicular to one another. The carboxylate hydroxyl group and the urethane carbonyl group form a strong intermolecular O—H?O hydrogen bond. |
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