Losartan potassium,a non‐peptide agent for the treatment of arterial hypertension |
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Authors: | Daniel Fernndez Daniel Vega Javier A Ellena Gustavo Echeverría |
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Institution: | Daniel Fernández,Daniel Vega,Javier A. Ellena,Gustavo Echeverría |
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Abstract: | In the title compound, potassium 2‐butyl‐4‐chloro‐1‐{2′‐(5‐tetrazolido)biphenyl‐4‐yl]methyl}‐1H‐imidazol‐5‐ylmethanol, K+·C22H22ClN6O?, the imidazole and tetrazole rings are at angles of 85.0 (2) and 51.8 (1)°, respectively, to the phenyl rings to which they are attached, while the dihedral angle between the latter two rings is 46.7 (1)°. The coordination sphere of the metal cation consists of six tetrazoyl N atoms, the methanol O atom and the π cloud of one of the phenyl rings. These interactions determine the formation of columns of molecular anions that lie parallel to the b axis, while hydrogen bonding contributes to intercolumnar cohesion. Far from the centre of the columns, the hydrocarbon chain is immersed in a hydrophobic environment. |
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