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Chemo- and regioselective ethynylation of 4,5,6,7-tetrahydroindoles with ethyl 3-halo-2-propynoates |
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| Authors: | Boris A. Trofimov, Lyubov&#x N. Sobenina, Zinaida V. Stepanova, Ol&#x ga V. Petrova, Igor&#x A. Ushakov,Al&#x bina I. Mikhaleva |
| Affiliation: | aA. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russian Federation |
| Abstract: | 4,5,6,7-Tetrahydroindoles undergo a rapid, facile (rt, 60 min) ethynylation with ethyl 3-halo-2-propynoates upon grinding with solid K2CO3 (without solvent) at C-2 of the tetrahydroindole ring to afford ethyl 3-(4,5,6,7-tetrahydroindol-2-yl)-2-propynoates in 62–90% yield. |
| Keywords: | 4,5,6,7-Tetrahydroindoles Indoles Active surface K2CO3 Cross-coupling |
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